World News – GB – Derivation of basal respiratory stem cells from human pluripotent stem cells – Docwire News


The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad implications for regenerative medicine Here we report the site-directed differentiation of human iPSCs into basal cells respiratory tract (“iBC”), a stem cell-like population of the respiratory tract epithelium Using a dual fluorescent reporter system (NKX2-1GFP; TP63tdTomato), we track and purify these cells at as they emerge as developmentally immature NKX2-1GFP lung progenitors, then augment a TP63 program during epithelial structuring of the proximal airways In response to the primary basal cell medium, NKX2-1GFP / TP63tdTomato cells display the molecular and functional phenotype of basal airway cells, including the ability to self-renew or undergo multi-line differentiation in vitro and in xenografts. tracheal in vivo Disturbances of ICBs and their differentiated progeny patterns that characterize acquired and genetic airway disease including mucosal metaplasia of asthma, chloride channel dysfunction of cystic fibrosis, and ciliary abnormalities of dyskinesia primary ciliary

Stem cell, tissue, pluripotency, induced pluripotent stem cell, industry, forecast

World news – GB – Derivation of basal airway stem cells from human pluripotent stem cells – Docwire News



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